Activation of the Farnesoid X Receptor Induces Hepatic Expression and Secretion of Fibroblast Growth Factor 21

Background: The hormone FGF21 is a potent regulator of carbohydrate and lipid metabolism and a promising drug for treating metabolic syndrome.Results: Farnesoid X receptor (FXR) agonists and FGF19 induce hepatic FGF21 secretion via a transcriptional mechanism and posttranscriptional mechanism, respectively.Conclusion: Activation of the FXR pathway stimulates FGF21 expression and secretion.Significance: Activation of FXR is a potential approach to enhance endogenous FGF21 production and reverse metabolic syndrome. Background: The hormone FGF21 is a potent regulator of carbohydrate and lipid metabolism and a promising drug for treating metabolic syndrome. Results: Farnesoid X receptor (FXR) agonists and FGF19 induce hepatic FGF21 secretion via a transcriptional mechanism and posttranscriptional mechanism, respectively. Conclusion: Activation of the FXR pathway stimulates FGF21 expression and secretion. Significance: Activation of FXR is a potential approach to enhance endogenous FGF21 production and reverse metabolic syndrome.