医学
疾病
机制（生物学）
神经科学
阿尔茨海默病
认知
氧化损伤
氧化应激
生物信息学
精神科
病理
内科学
生物
认识论
哲学
作者
Henry Querfurth,Frank M. LaFerla
标识
DOI：10.1056/nejmra0909142
摘要
This review of Alzheimer's disease assembles a variety of findings relevant to the mechanism of the disease and ties them together using the current understanding of the basis of the loss of cognition: the accumulation of misfolded proteins, which cause oxidative and inflammatory damage to the brain and, ultimately, synaptic dysfunction.
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