已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

ADEQUACY OF SIGMOIDOSCOPY IN COMPARISION TO COLONOSCOPY TO ASSESS DISEASE ACTIVITY DURING FOLLOW UP IN PATIENTS WITH ULCERATIVE COLITIS

医学 乙状结肠镜检查 结肠镜检查 溃疡性结肠炎 内科学 胃肠病学 内窥镜检查 炎症性肠病 结肠炎
作者
Sameet Patel,Shubham Jain,Sanjay Chandnani,Prasanta Debnath,Qais Contractor,Seemily Kahmei,Rima N Kamat,Pravin Rathi
出处
期刊:Inflammatory Bowel Diseases [Oxford University Press]
卷期号:28 (Supplement_1): S31-S32
标识
DOI:10.1093/ibd/izac015.047
摘要

Abstract BACKGROUND Endoscopic remission is the current treatment target in patients with Ulcerative Colitis (UC). Literature on adequacy of sigmoidoscopy in comparison to colonoscopy to assess endoscopic and histologic activity during follow up is sparse. METHODS This is an interim analysis of a prospective study of patients diagnosed with UC with disease extent proximal to the sigmoid colon. Fifty adult patients underwent a complete colonoscopy with segmental biopsies. Endoscopic disease activity was graded using Mayo Endoscopic Subscore (MES) and the Ulcerative Colitis Endoscopic Index of Severity score (UCEIS). The histological grading was done using the Nancy score, Robarts Histopathology Index (RHI) and Simplified Geboes Score (SGS). The maximum rectosigmoid disease activity was compared with the maximum disease activity in the rest of the colon. RESULTS Endoscopic Correlation: Sigmoidoscopic evaluation using MES showed good correlation with pan colonoscopic evaluation for disease activity with a sensitivity of 92.11%, specificity of 66.67%, accuracy of 86% (95% CI – 73.26% to 94.18%), kappa value (k) of 0.58 (p value < 0.001) and Area under curve (AUC) of 0.82 (95% CI- 0.74 to 0.942). Similarly, sigmoidoscopic evaluation using UCEIS score showed good correlation with pan colonoscopic evaluation for disease activity with a sensitivity of 95.0%, specificity of 70%, accuracy of 90% (95% CI – 78.19% to 96.67%), k of 0.68 (p value < 0.001) and AUC of 0.895 (95% CI- 0.805 to 0.924). Disease activity in the colon missed by performing a sigmoidoscopy using MES and UCEIS score is only 6% and 4% respectively. Histological Correlation: Histologic findings in rectosigmoid showed good correlation with histologic findings in rest of the colon using Nancy’s score [Sensitivity of 97.96%, specificity of 100%, accuracy of 98% (95% CI – 89.35% to 99.95%), k of 0.658 (p value < 0.001) and AUC of 0.99 (95% CI- 0.959 to 1.0)], Simplified Geboes Score [Sensitivity of 97.92%, specificity of 100%, accuracy of 98% (95% CI – 89.35% to 99.95%), k of 0.79 (p value < 0.001) and AUC of 0.99 (95% CI- 0.962 to 1.0)], and Robarts Histopathology Index [Sensitivity of 95.56%, specificity of 80%, accuracy of 94% (95% CI – 83.45% to 98.75%), k of 0.694 (p value < 0.001) and AUC of 0.878 (95% CI- 0.667 to 1.0) ]. Histologic disease activity in the colon missed by performing a sigmoidoscopy using Nancy score, SGS and RHI is only 2%, 2% and 4% respectively. CONCLUSION In patients diagnosed with UC and having disease extent proximal to the sigmoid colon, sigmoidoscopic evaluation has good correlation with pan colonoscopic evaluation for grading endoscopic and histological disease activity. A sigmoidoscopic examination is adequate to assess the disease activity in patients with disease extent proximal to the sigmoid colon.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
笑而不语完成签到 ,获得积分10
1秒前
辛苦科研人完成签到 ,获得积分10
2秒前
3秒前
7秒前
恋雅颖月应助称心的思卉采纳,获得10
8秒前
yinjw发布了新的文献求助30
8秒前
WuYiHHH发布了新的文献求助10
8秒前
活泼的面包完成签到 ,获得积分10
12秒前
loong发布了新的文献求助10
13秒前
14秒前
orixero应助1234采纳,获得10
18秒前
18秒前
希望天下0贩的0应助loong采纳,获得10
18秒前
zsw发布了新的文献求助10
23秒前
27秒前
29秒前
30秒前
ding应助Iris采纳,获得10
34秒前
难过大神发布了新的文献求助10
35秒前
吃醋的喵酱完成签到,获得积分10
38秒前
38秒前
39秒前
赘婿应助hyhyhyhy采纳,获得10
41秒前
腼腆的修杰完成签到 ,获得积分10
41秒前
潘善若发布了新的文献求助10
42秒前
一直向前发布了新的文献求助10
44秒前
honeylaker发布了新的文献求助10
45秒前
bkagyin应助zsw采纳,获得10
45秒前
45秒前
46秒前
46秒前
斯文败类应助科研通管家采纳,获得10
46秒前
共享精神应助科研通管家采纳,获得10
46秒前
科研通AI2S应助科研通管家采纳,获得10
46秒前
Owen应助科研通管家采纳,获得10
46秒前
脑洞疼应助科研通管家采纳,获得10
47秒前
CipherSage应助科研通管家采纳,获得10
47秒前
我是老大应助科研通管家采纳,获得10
47秒前
1234发布了新的文献求助10
48秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989868
求助须知:如何正确求助?哪些是违规求助? 3531994
关于积分的说明 11255752
捐赠科研通 3270793
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882215
科研通“疑难数据库(出版商)”最低求助积分说明 809208