2-Benzofuran-1(3H)-ones (isobenzofuranons) are multi-function precursors toward a variety of cyclic compounds as isobenzofuranon structure is ubiquitous in many natural products.Due to its extensive biological activity and wide application in medicinal chemistry, the preparation of these compounds has attracted great attention.In this paper, our and other research groups' work on the synthesis of isobenzofuranone in recent ten years from three aspects of transition metal catalytic synthesis, acid-base catalytic synthesis and other synthesis methods is summarized.