Palladium‐Catalyzed Selective C‐F Bond Cleavage of Trifluoropropanamides Leading to (Z)‐N‐α‐Fluorovinylindoles

Abstract A defluorinative heteroarylation of trifluoropropanamides through N ‐chelation‐assisted palladium‐catalyzed selective C−F activation has been developed. This reaction is compatible with a variety of trifluoropropanamides and indoles under mild reaction conditions to provide the stereospecific ( Z )‐ N ‐α‐fluorovinylindoles in moderate to good yields. magnified image