Vinyl fluorosulfonamide: a practical vinyl electrophilic reagent for mild and efficient synthesis of ketones under catalyst- and additive-free conditions

A catalyst- and additive-free hydrolysis of alkenyl fluorosulfonamides is achieved, providing an efficient approach for the synthesis of various aryl ketones in moderate to excellent yields. This reaction exhibits broad functional group compatibility without the formation of undesired desulfonation compounds. Moreover, the procedure operates under the mild conditions avoiding the use of additional metal catalysts or potential security risk substrate (vinyl azide), and the reaction finishes in short reaction time (30 min) at room temperate.