乙酰化
皂化
甲醇钠
化学
水解
甲醇
甲醇
有机化学
二硫键
碳水化合物
催化作用
生物化学
基因
标识
DOI:10.1002/9780470638859.conrr691
摘要
Abstract The efficient removal of the O ‐acetyl protecting groups of carbohydrates by treatment of the O ‐acetylated substrates in methanol with a catalytic amount of sodium methoxide at room temperature is generally known as the Zemplén deacetylation, Zemplén de‐ O ‐acetylation, or Zemplen deacetylation. In addition, after the reaction, the O ‐acetyl‐protected carbohydrates are transformed into unprotected ones, in a manner analogous to the hydrolysis of an ester, thus this reaction is termed as the Zemplen saponification as well. However, it has been reported that the Zemplén deacetylation is probably not suitable for the deprotection of carbohydrates with disulfide linkages. This reaction has wide applications in carbohydrate chemistry.
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