Phase II OVARIO study of niraparib + bevacizumab therapy in advanced ovarian cancer following front-line platinum-based chemotherapy with bevacizumab

Objective: Niraparib improves progression-free survival (PFS) in newly diagnosed and recurrent ovarian cancer (OC) in patients after platinum-based chemotherapy in all biomarker-defined subgroups. OVARIO (NCT03326193) is a single-arm study evaluating niraparib + bevacizumab treatment in advanced OC after response to first-line platinum-based chemotherapy + bevacizumab.