P2–371: A multicenter, randomized trial to assess efficacy of home‐based and group cognitive intervention programs in amnestic mild cognitive impairment

The efficacy of cognitive intervention programs remains to be verified using a randomized trial with standardized intervention in mild cognitive impairment (MCI). The effectiveness of home-based cognitive intervention programs have never been studied in MCI. The objective of this study was to investigate the efficacy of a group cognitive intervention and a home-based cognitive intervention about cognitive function in amnestic MCI (aMCI). Using a randomized control design, 297 participants with MCI were randomly assigned to a group cognitive intervention, a home-based cognitive intervention, or waitlist control group. The intervention was a multicomponent cognitive intervention which focused on teaching prospective and episodic memory strategies and using them in their daily life. Participants were assessed on primary measure of the modified Alzheimer Disease Assessment Scale-cognitive subscale (ADAS-Cog) at baseline, post-intervention, and 12 weeks' and 24 weeks' follow-up. Secondary measures evaluated memory, cognition, behavior, quality of life, and function. Overall, 99 and 98 participants received group cognitive intervention and home-based cognitive intervention, respectively, for 12weeks. Of these, about 70% of the participants completed the intervention. We noted a significant decrease in modified ADAS-Cog (-2.7±6.1 vs. -0.82±5.1, p =0.02) and Clinical Dementia Rating Sum of Boxes (CDR-SB) scores (-0.21±0.64 vs. 0.04±0.56, p =0.01) in favor of home-based cognitive intervention compared to the waitlist control group at the post-intervention point. There was a significant group effect on modified ADAS-cog through the all assessment points between home-based cognitive intervention and controls (p =0.02). The interaction effect on modified ADAS-cog was significant between the assessment phase effect and the group (group cognitive intervention versus controls) (p =0.048). Home-based cognitive intervention and group cognitive intervention could be useful to improve cognition in aMCI.