Age dependency for coagulation parameters in paediatric populations

医学 抗凝血酶 凝结 混凝试验 儿科 血栓形成 内科学 年龄组 胃肠病学 肝素 人口学 社会学
作者
Pierre Toulon,M. Berruyer,Marie Brionne‐François,François Grand,Dominique Lasne,C. Télion,Julien Arcizet,Roberta Giacomello,Neila De Pooter
出处
期刊:Thrombosis and Haemostasis [Thieme Medical Publishers (Germany)]
卷期号:116 (07): 9-16 被引量:84
标识
DOI:10.1160/th15-12-0964
摘要

Summary Understanding of developmental haemostasis is critical to ensure optimal prevention, diagnosis, and treatment of haemorrhagic and thrombotic diseases in children. As coagulation test results are known to be dependent on the reagents/analysers used, it is recommended for each laboratory to define the age-dependent reference ranges by using its own technical condition. That study was carried out in seven centers to establish age-specific reference ranges using the same reagents and analyser. Plasma samples were obtained from 1437 paediatric patients from the following age groups: 15 days-4 weeks (n=36), 1–5 months (n=320), 6–12 months (n=176), 1–5 years (n=507), 6–10 years (n=132) and 11–17 years (n=262). Indication of coagulation testing was pre-operative screening for non-acute diseases in most cases. PT values were similar in the different age groups to those in adults, whereas longer aPTTs were demonstrated in the younger children. Plasma levels of all clotting factors, except for FV, were significantly decreased (p<0.0001) in the youngest children, adult values being usually reached before the end of the first year. The same applied to antithrombin, protein C/S, and plasminogen. In contrast, FVIII and VWF levels were elevated in the youngest children and returned to adult values within six months. The same applied to D-dimer levels, which were found elevated, particularly until six months of life, until puberty. These data suggest that most coagulation test results are highly dependent on age, mainly during the first year of life, and that age-specific reference ranges must be used to ensure proper evaluation of coagulation in children.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
阿Q完成签到,获得积分10
1秒前
2秒前
上将军顺完成签到,获得积分10
2秒前
Hollow发布了新的文献求助10
3秒前
qwaz完成签到,获得积分10
5秒前
5秒前
脑洞疼应助julien采纳,获得10
5秒前
852应助生医工小博采纳,获得10
6秒前
6秒前
喽喽完成签到,获得积分10
6秒前
叽里呱啦发布了新的文献求助10
6秒前
Ava应助Hollow采纳,获得10
9秒前
氮化硼小兵给氮化硼小兵的求助进行了留言
10秒前
13秒前
今后应助老乔采纳,获得10
15秒前
小蘑菇应助lunjianchi采纳,获得10
15秒前
刘佳冉完成签到,获得积分10
16秒前
16秒前
17秒前
淡然善斓完成签到,获得积分10
18秒前
要减肥的惜萱完成签到,获得积分10
19秒前
行路人发布了新的文献求助20
19秒前
整齐冬瓜完成签到,获得积分10
20秒前
xlxl发布了新的文献求助30
20秒前
Hello应助峰1992采纳,获得10
21秒前
22秒前
23秒前
Akim应助upsoar采纳,获得10
23秒前
23秒前
23秒前
LZQ应助wjw采纳,获得10
24秒前
FashionBoy应助孟古采纳,获得10
24秒前
科研通AI2S应助demian采纳,获得10
26秒前
踏雪飞鸿发布了新的文献求助10
27秒前
29秒前
30秒前
沈DJ发布了新的文献求助10
30秒前
spp完成签到 ,获得积分0
32秒前
34秒前
和谐的巨人完成签到 ,获得积分10
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3967419
求助须知:如何正确求助?哪些是违规求助? 3512730
关于积分的说明 11164792
捐赠科研通 3247704
什么是DOI,文献DOI怎么找? 1793978
邀请新用户注册赠送积分活动 874785
科研通“疑难数据库(出版商)”最低求助积分说明 804517