纳米反应器
葡萄糖氧化酶
葡萄糖酸
过氧化氢
过氧化物酶
化学
金属有机骨架
组合化学
人工酶
级联反应
生物传感器
纳米技术
酶
材料科学
催化作用
有机化学
生物化学
吸附
作者
Tong Li,Huiqiang Qiu,Na Liu,Jia Li,Yuheng Bao,Weijun Tong
标识
DOI:10.1016/j.colsurfb.2020.111001
摘要
Metal organic frameworks (MOFs) served as peroxidase-like artificial enzymes have been recently adopted for wide applications including therapy, pollution degradation, biosensing and so on. However, most of MOFs mimicking peroxidase cannot perform with the utmost efficiency under certain biological circumstances, such as bacterial infections. This is mainly because that the peroxidase-like MOFs exhibit highest activity at pH of 3-4, while bacterial infections cannot lower the environmental pH to the optimal value. This problem significantly restrains the therapy effect. Herein, self-activated cascade MOF/enzyme hybrid nanoreactors ([email protected] NRs) based on MIL (Materials of Institute Lavoisier) and GOx (Glucose oxidase) were successfully constructed through a two-step procedure. GOx was successfully loaded in the MIL shells and onto their surface as well. The GOx can catalyze the production of gluconic acid that reduces the pH value to around 4, at which the [email protected] NRs perform the highest cascade reaction activity. The continually produced hydrogen peroxide (H2O2) can be subsequently catalyzed by MIL NPs to generate highly toxic hydroxyl radicals (HO•) for antibacterial application. Thus, [email protected] NRs can significantly inhibit methicillin-resistant staphylococcus aureus (MRSA) growth and biofilm formation.
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