Sensitive Untargeted Screening of Nerve Agents and Their Degradation Products Using Liquid Chromatography–High Resolution Mass Spectrometry

化学 神经毒剂 碰撞诱导离解 质谱法 碎片(计算) 色谱法 离解(化学) 组合化学 串联质谱法 检出限 分析化学(期刊) 有机化学 计算机科学 操作系统 乙酰胆碱酯酶
作者
Meijuan Zhang,Yulong Liu,Jia Chen,Lei Zhu,Xiaogang Lu,Jianfeng Wu,Yajiao Zhang,Ying‐Hsuan Lin,Qin Liu,Hongmei Wang,Lei Guo,Runli Gao,Bin Xu,Jianwei Xie
出处
期刊:Analytical Chemistry [American Chemical Society]
卷期号:92 (15): 10578-10587 被引量:25
标识
DOI:10.1021/acs.analchem.0c01508
摘要

Nerve agents (NAs) are notorious chemical warfare agents that pose a serious threat to national security and public health. The total number of theoretical chemicals of NAs and their degradation products (DPs) exceeds 410 000, according to 1.A.01–1.A.03 in the Schedules of Chemicals of the Chemical Weapons Convention, which poses great challenges for identification and verification. A three-step integrated untargeted screening strategy was developed based on high-resolution mass spectrometry. First, an extensible homemade library for targeted screening of common classical agents was established. Second, a set of in-source collision-induced dissociation mass spectrometry (MS)-alerting ions was extracted and concluded based on fragmentation behavior studies, which included 40 specific alerting ions and 10 types of characteristic structural fragments from total NAs and their DPs. A novel "alerting ion" searching method was developed to rapidly and sensitively screen whether or not nerve agent-related compounds were present and of which type they were. Third, we built a theoretical exact mass database including 202 accurate masses or molecular formulas, which could cover all structural possibilities of the NAs and their DPs. Comprehensively, the elemental composition of pseudomolecular ions, fragment ions, MS/MS spectra, and isotope pattern information were obtained from the full scan MS/data dependent-MS2 experiments and elucidated for identification of the candidates selected in the screening step. This strategy was successfully applied to the identification of unknown chemicals in real samples with good stability and a low limit of detection of 1–10 ng/mL. These procedures are applicable for trace forensic investigations in cases of the alleged use of nerve agents.
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