作者
Isaac Klein,Ann Boija,Lena K. Afeyan,Susana Wilson Hawken,Mengyang Fan,Alessandra Dall’Agnese,Ozgur Oksuz,Jonathan E. Henninger,Krishna Shrinivas,Benjamin R. Sabari,Ido Sagi,Victoria Clark,Jesse M. Platt,Mrityunjoy Kar,Patrick M. McCall,Alicia V. Zamudio,John C. Manteiga,Eliot L. Coffey,Charles H. Li,Nancy M. Hannett,Yang Guo,Tim-Michael Decker,Tong Ihn Lee,Tinghu Zhang,Jing‐Ke Weng,Dylan J. Taatjes,Arup K. Chakraborty,Phillip A. Sharp,Young‐Tae Chang,Anthony A. Hyman,Nathanael S. Gray,Richard A. Young
摘要
Drug partitioning in nuclear condensates There is increasing interest in the function of phase-separated biomolecular condensates in cells because of their distinct properties and expanding roles in important biological processes. Klein et al. considered the fate of small-molecule therapeutics in the context of nuclear condensates (see the Perspective by Viny and Levine). They show that certain antineoplastic drugs have physicochemical properties that cause them to concentrate preferentially in condensates, both in vitro and in cancer cells. This property influences drug activity, and protein mutations that alter condensate formation can lead to drug resistance. Optimizing condensate partitioning may be valuable in developing improved therapeutics. Science , this issue p. 1386 ; see also p. 1314