过氧化氢
病态的
生物标志物
癌症
石墨烯
材料科学
癌症研究
病理
化学
纳米技术
医学
生物化学
内科学
作者
Yu Yan,Jinrong Peng,Meng Pan,Moon‐Sik Yang,Yan Li,Liping Yuan,Qingya Liu,Ruxia Han,Ying Hao,Yun Yang,Danrong Hu,He Li,Zhiyong Qian
标识
DOI:10.1002/smtd.202001212
摘要
The diagnosis of malignant tumors is essential for informing clinical decisions regarding therapeutic options. Current imaging and pathological diagnostic methods do not provide quantitative molecular information that is important in tumor identification. Moreover, pathological tissue analysis is dependent on unevenly distributed pathological features. The tumor microenvironment has been documented to have hydrogen peroxide (H2 O2 ). This study presents a biologically sensitive and efficient H2 O2 electrochemical sensor based on PtNi nanoparticle-doped N-reduced graphene oxide (PtNi-N-rGO) with a low detection limit (2.8 × 10-9 m), a fast response time (<6 s) and desirable anti-interference characteristics. Herein, H2 O2 is used as molecular biomarker. The sensor successfully captures H2 O2 from cancer cells. In addition, it efficiently detects tumor tissues, adjacent tissues, and normal tissues. This study demonstrates the H2 O2 sensor potential to rapidly detect tumor tissues. This technique provides a complementary method for pathological tumor diagnosis that is independent of the traditional pathology labs.
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