癌症研究
免疫增强剂
光动力疗法
癌细胞
免疫疗法
佐剂
转移
癌症免疫疗法
免疫系统
CpG寡核苷酸
肿瘤缺氧
医学
癌症疫苗
癌症
免疫学
化学
内科学
放射治疗
生物化学
基因表达
有机化学
DNA甲基化
基因
作者
Zhixiong Cai,Fuli Xin,Zuwu Wei,Ming Wu,Xinyi Lin,Xiaofan Du,Geng Chen,Da Zhang,Zhenxi Zhang,Xiaolong Liu,Cuiping Yao
标识
DOI:10.1002/adhm.201900996
摘要
Abstract Photodynamic therapy (PDT) usually aggravates tumor hypoxia, which promotes the survival and metastasis of residue cancer cells; furthermore, although PDT‐induced immunogenic death of cancer cells can induce host antitumor responses, such responses are generally weak and not enough to eliminate the residue cancer cells. Here, metal–organic framework (MOF)‐based nanoparticles to combine PDT, antihypoxic signaling, and CpG adjuvant as an in situ tumor vaccine to boost host anticancer responses after PDT are designed. The MOF‐based nanoparticles are self‐assembled from H 2 TCPP and zirconium ions with hypoxia inducible factor (HIF) signaling inhibitor (ACF) and immunologic adjuvant (CpG) loading, and hyaluronic acid (HA) coating on the surface. The final nanoparticles (PCN‐ACF‐CpG@HA) can specifically target cancer cells overexpressing CD44 receptor though HA; the aggravated hypoxic survival signaling after PDT can be blocked by ACF to inhibit the HIF‐1α induced survival and metastasis. With the help of CpG adjuvant, the tumor associated antigens generated from PDT‐based cancer cell destruction can initiate strong antitumor immune responses to eliminate residue cancer cells. Taken together, a novel in situ immunostimulatory strategy is designed to synergistically enhance therapeutic effects of PDT by activating host antitumor immune‐responses both in vitro and in vivo, which may have great potential for clinical translation in future.
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