Comparative study on formation of protein coronas under three different serum origins

化学 纳米颗粒 纳米材料 生物流体 血液蛋白质类 体内 人口 生物物理学 纳米技术 生物化学 生物 色谱法 材料科学 生物技术 人口学 社会学
作者
Sun Young Lee,Jin Gyeong Son,Jeong Hee Moon,Sunho Joh,Tae Geol Lee
出处
期刊:Biointerphases [American Institute of Physics]
卷期号:15 (6) 被引量:11
标识
DOI:10.1116/6.0000396
摘要

Nanomaterials form a complex called “protein corona” by contacting with protein-containing biological fluids such as serum when they are exposed to physiological environments. The characteristics of these proteins, which are one of the substantial factors in cellular response, are affected by the interactions between the nanomaterials and the biological systems. Many studies have investigated the biological behaviors of nanomaterials by conducting experiments in vitro and in vivo; however, the origin of the biological materials used is rather inconsistent. This is due to the fact that the composition of the protein coronas may differ depending on the animal origin, not on the composition or size of the nanoparticles. The resulting differences in the composition of the protein coronas can lead to different conclusions. To identify the differences in protein corona formation among sera of different species, we investigated protein coronas of gold and silica nanoparticles in serum obtained from various species. Using comparative proteomic analysis, common proteins adsorbed onto each nanoparticle among the three different sera were identified as highly abundant proteins in the serum. These findings indicate that protein corona formation is dependent on the serum population rather than the size or type of the nanoparticles. Additionally, in the physiological classification of protein coronas, human serum (HS) was found to be rich in apolipoproteins. In conclusion, our data indicate that HS components are different from those of bovine or mouse, indicating that the serum species origin should be carefully considered when selecting a biological fluid.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
漫漫发布了新的文献求助10
刚刚
天才罗完成签到 ,获得积分10
刚刚
najibveto发布了新的文献求助10
1秒前
冷艳的晟睿完成签到 ,获得积分10
1秒前
vn完成签到,获得积分10
1秒前
momo完成签到,获得积分10
1秒前
傲娇黄豆完成签到,获得积分10
2秒前
ming完成签到,获得积分10
2秒前
华仔应助謓言采纳,获得10
3秒前
直率书芹完成签到,获得积分10
3秒前
内向白开水完成签到,获得积分10
3秒前
找文献呢完成签到,获得积分10
3秒前
香菜完成签到 ,获得积分10
3秒前
hh完成签到 ,获得积分10
4秒前
林子觽完成签到,获得积分10
5秒前
zbclzf完成签到,获得积分10
5秒前
6秒前
研友_ZbP41L完成签到 ,获得积分10
6秒前
木勿忘完成签到,获得积分10
6秒前
山本无山完成签到 ,获得积分10
6秒前
动听安筠完成签到 ,获得积分10
6秒前
默默尔安完成签到 ,获得积分10
7秒前
zy完成签到,获得积分10
8秒前
六六完成签到,获得积分10
8秒前
念姬完成签到,获得积分10
9秒前
10秒前
yuan完成签到,获得积分10
10秒前
zzx完成签到,获得积分10
10秒前
aka完成签到,获得积分10
11秒前
dx105完成签到,获得积分10
11秒前
自信的寒天完成签到,获得积分10
11秒前
bqin完成签到,获得积分20
12秒前
12秒前
乐乐发布了新的文献求助10
14秒前
14秒前
天天哥哥完成签到 ,获得积分10
14秒前
zxp完成签到,获得积分10
15秒前
车剑锋完成签到,获得积分10
16秒前
聪明的破茧完成签到,获得积分10
16秒前
aki空中飞跃完成签到,获得积分10
16秒前
高分求助中
Lire en communiste 1000
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 800
Becoming: An Introduction to Jung's Concept of Individuation 600
Communist propaganda: a fact book, 1957-1958 500
Briefe aus Shanghai 1946‒1952 (Dokumente eines Kulturschocks) 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3167282
求助须知:如何正确求助?哪些是违规求助? 2818798
关于积分的说明 7922523
捐赠科研通 2478563
什么是DOI,文献DOI怎么找? 1320404
科研通“疑难数据库(出版商)”最低求助积分说明 632776
版权声明 602443