复合数
多孔性
溶剂
海绵
银纳米粒子
海藻酸钠
抗菌剂
材料科学
纳米技术
化学
化学工程
抗菌活性
纳米
纳米颗粒
钠
复合材料
细菌
有机化学
生物
植物
工程类
遗传学
作者
Limei Liang,Tingting Hou,Qianqian Ouyang,Lei Xie,Saiyi Zhong,Puwang Li,Sidong Li,Cheng‐Peng Li
标识
DOI:10.1016/j.compositesb.2020.107877
摘要
To endow antibacterial activity and maintain good porosity, oxidized sodium alginate (OSA) sponge was functionalized via polydopamine/silver composite nanospheres (PDA/AgNSs). It is found that uniform PDA spheres (around 1.7 μm) can be successfully coated on OSA sponge surface without compromise of the OSA sponge integrity and porosity using absolute ethanol as optimized solvent. Particularly, the newly-produced PDA spheres can crosslink with the OSA sponge via the Schiff-base condensation, leading to improved stability. On the other hands, those PDA spheres can be served as the active sites to realize the growth of silver nanoparticles (around 50–70 nm) on PDA spheres surface, leading to the formation of novel PDA/AgNSs. Further analysis indicates that our proposed OSA/PDA/AgNSs sponge shows high blood compatibility, low cell cytotoxicity, good hemostatic performance as well as superior inhibitory activity against P. aeruginosa, S. aureus and E. coli. In conclusions, our proposed strategy opens a new route for antimicrobial sodium alginate dressing development.
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