甘草
化学
消炎药
根茎
传统医学
甘草
槲皮素
一氧化氮
药理学
生物化学
抗氧化剂
生物
有机化学
医学
病理
替代医学
作者
Liyao Wang,Kaixue Zhang,Shu Han,Liu Zhang,Hai-Ying Bai,Fang Bao,Yan Zeng,Li Wang,Hong Du,Ying‐Qian Liu,Zhigang Yang
出处
期刊:Molecules
[MDPI AG]
日期:2019-05-18
卷期号:24 (10): 1923-1923
被引量:33
标识
DOI:10.3390/molecules24101923
摘要
Licorice, the root and rhizome of Glycyrrhiza uralansis Fisch, is one of the most frequently used Traditional Chinese Medicines in rigorous clinical trials to remove toxins and sputum, and to relieve coughing. However, the aerial parts are not used so widely at present. It has been reported that the aerial parts have many bioactivities such as anti-microbial and anti-HIV activities. In this study, we aimed to discover the bioactive compounds from the leaves of G. uralensis. Four new compounds, licostilbene A-B (1-2) and licofuranol A-B (3-4), together with eight known flavonoids (5-12), were isolated and identified from the leaves of G. uralensis. Their structures were elucidated mainly by the interpretation of high-resolution electrospray mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR) spectroscopic data. Compared with quercetin, which showed a 50% inhibitory concentration (IC50) value of 4.08 μg/mL, compounds 1-9 showed significant anti-inflammatory activities by inhibiting lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 2.60, 2.15, 3.21, 3.25, 2.00, 3.45, 2.53, 3.13 and 3.17 μg/mL, respectively. The discovery of these active compounds is important for the prevention and treatment of inflammation.
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