内质网
免疫原性细胞死亡
光热治疗
光动力疗法
程序性细胞死亡
癌症研究
癌症
细胞
医学
癌细胞
细胞生物学
癌症治疗
细胞凋亡
化学
生物
纳米技术
材料科学
生物化学
内科学
有机化学
作者
Wei Li,Jie Yang,Lihua Luo,Mengshi Jiang,Bing Qin,Hang Yin,Chunqi Zhu,Xian‐You Yuan,Junlei Zhang,Zhenyu Luo,Yong‐Zhong Du,Qingpo Li,Yan Lou,Yunqing Qiu,Jian You
标识
DOI:10.1038/s41467-019-11269-8
摘要
Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress. In this study, we generate a double ER-targeting strategy to realize photodynamic therapy (PDT) photothermal therapy (PTT) immunotherapy. This nanosystem consists of ER-targeting pardaxin (FAL) peptides modified-, indocyanine green (ICG) conjugated- hollow gold nanospheres (FAL-ICG-HAuNS), together with an oxygen-delivering hemoglobin (Hb) liposome (FAL-Hb lipo), designed to reverse hypoxia. Compared with non-targeting nanosystems, the ER-targeting naosystem induces robust ER stress and calreticulin (CRT) exposure on the cell surface under near-infrared (NIR) light irradiation. CRT, a marker for ICD, acts as an 'eat me' signal to stimulate the antigen presenting function of dendritic cells. As a result, a series of immunological responses are activated, including CD8+ T cell proliferation and cytotoxic cytokine secretion. In conclusion, ER-targeting PDT-PTT promoted ICD-associated immunotherapy through direct ROS-based ER stress and exhibited enhanced anti-tumour efficacy.
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