线粒体
活性氧
细胞生物学
细胞内
程序性细胞死亡
化学
细胞
生物物理学
细胞凋亡
材料科学
生物化学
生物
作者
Jinhua Li,Meng Jiang,Huaijuan Zhou,Ping Jin,Kmc Cheung,Paul K. Chu,Kwk Yeung
标识
DOI:10.1002/gch2.201800058
摘要
Abstract A biomaterials surface enabling the induction of tumor cell death is particularly desirable for implantable biomedical devices that directly contact tumor tissues. However, this specific antitumor feature is rarely found. Consequently, an antitumor‐cell nanocoating comprised of vanadium dioxide (VO 2 ) prepared by customized reactive magnetron sputtering has been proposed, and its antitumor‐growth capability has been demonstrated using human cholangiocarcinoma cells. The results reveal that the VO 2 nanocoating is able to interrupt the mitochondrial electron transport chain and then elevate the intracellular reactive oxygen species levels, leading to the collapse of the mitochondrial membrane potential and the destruction of cell redox homeostasis. Indeed, this chain reaction can effectively trigger oxidative damage in the cholangiocarcinoma cells. Additionally, this study has provided new insights into designing a tumor‐cell‐inhibited biomaterial surface, which is modulated by the mechanism of mitochondria‐targeting tumor cell death.
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