微生物群
放射治疗
共生
生物
乳腺癌
抗生素
癌症研究
免疫功能障碍
免疫学
免疫疗法
黑色素瘤
癌症
免疫系统
细菌
微生物学
医学
生物信息学
内科学
遗传学
作者
Stephen L. Shiao,Kathleen M. Kershaw,Jose J. Limon,Sungyong You,Junhee Yoon,Emily Ko,Jlenia Guarnerio,Alka A. Potdar,Dermot McGovern,Shikha Bose,Mandar Patgaonkar,Paul Noe,Jung Lee,Yuzu Kubota,Viviana I. Maymí,Madison Davis,Regina M. Henson,Rachel Y. Choi,Wensha Yang,Jie Tang
出处
期刊:Cancer Cell
[Cell Press]
日期:2021-07-29
卷期号:39 (9): 1202-1213.e6
被引量:192
标识
DOI:10.1016/j.ccell.2021.07.002
摘要
Studies suggest that the efficacy of cancer chemotherapy and immunotherapy is influenced by intestinal bacteria. However, the influence of the microbiome on radiation therapy is not as well understood, and the microbiome comprises more than bacteria. Here, we find that intestinal fungi regulate antitumor immune responses following radiation in mouse models of breast cancer and melanoma and that fungi and bacteria have opposite influences on these responses. Antibiotic-mediated depletion or gnotobiotic exclusion of fungi enhances responsiveness to radiation, whereas antibiotic-mediated depletion of bacteria reduces responsiveness and is associated with overgrowth of commensal fungi. Further, elevated intratumoral expression of Dectin-1, a primary innate sensor of fungi, is negatively associated with survival in patients with breast cancer and is required for the effects of commensal fungi in mouse models of radiation therapy.
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