化学
对映选择合成
非共价相互作用
催化作用
组合化学
有机催化
手性(物理)
转移加氢
硅烷化
立体化学
有机化学
分子
氢键
手征对称破缺
物理
量子力学
夸克
钌
Nambu–Jona Lasinio模型
作者
Euijae Lee,Yeongyu Hwang,Yeong Bum Kim,Dongwook Kim,Sukbok Chang
摘要
Described herein is the Ir-catalyzed enantioselective access to chiral spirolactam products via the nitrenoid transfer to aromatic ipso-carbons. The key strategy for precise stereocontrol is to enhance the secondary attractive and repulsive interactions between the chiral catalyst and substrates by the introduction of a traceless O-silyl achiral auxiliary, thus effectively differentiating two prochiral faces of arenol-derived 1,4,2-dioxazol-5-one substrates.
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