瓜氨酸化
瓜氨酸
精氨酸
生物
中性粒细胞胞外陷阱
生物化学
细胞生物学
化学
计算生物学
氨基酸
免疫学
炎症
作者
Santanu Mondal,Paul R. Thompson
标识
DOI:10.1016/j.cbpa.2021.01.010
摘要
Citrullination is a post-translational modification (PTM) that converts peptidyl-arginine into peptidyl-citrulline; citrullination is catalyzed by the protein arginine deiminases (PADs). This PTM is associated with several physiological processes, including the epigenetic regulation of gene expression, neutrophil extracellular trap formation, and DNA-damage induced apoptosis. Notably, aberrant protein citrullination is relevant to several autoimmune and neurodegenerative diseases and certain forms of cancer. As such, the PADs are promising therapeutic targets. In this review, we discuss recent advances in the development of PAD inhibitors and activity-based probes, the development and use of citrulline-specific probes in chemoproteomic applications, and methods to site-specifically incorporate citrulline into proteins.
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