亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

[Metabolomics study of urine with Benzene, Toluene and Xylene combined exposure based on ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry].

二甲苯 代谢组学 化学 甲苯 尿 色谱法 代谢途径 质谱法 新陈代谢 环境化学 生物化学 有机化学
作者
X D Liu,Huang Qiao,C Wang,Xianshuang Meng,Xueying Pan,Dongling Niu,J Li
出处
期刊:Chinese Journal of Industrial Hygiene and Occupational Diseases [Chinese Medical Association]
卷期号:39 (4): 248-252
标识
DOI:10.3760/cma.j.cn121094-20200228-00092
摘要

Objective: To study the effects of combined occupational exposure of benzene, toluene, and xylene on human metabolism at an overall level, and to screen biomarkers related to the combined occupational exposure of benzene, toluene, and xylene, and to explore the mechanism of early health effects preliminarily caused by combined occupational exposure of benzene, toluene, and xylene by identification of biomarkers and retrieval of metabolic pathways. Methods: A shoe-making company was selected as the research site. Twenty subjects for the exposed group and the control group were selected separately, and urine of the subjects was collected. The metabolic profiles of the samples were collected by liquid chromatography time-of-flight mass spectrometry, and professional metabolomics and multivariate statistical analysis software were used to establish PCA and OPLS-DA analysis models to screen potential biomarkers and identify biomarkers. Finally, based on the dynamic changes and trends of potential biomarkers between groups, the mechanism of body damage caused by benzene, toluene, and xylene was initially explored. Results: Urine metabolomics analysis showed that the metabolic profile of urine samples of the benzene, toluene, and xylene combined exposure group was different from that of the control group. 27 potential biomarkers that were closely related to the combined exposure of benzene, toluene, and xylene were screened and identified. These potential biomarkers were enriched in 16 metabolic pathways, of which 3 pathways were significantly enriched (P<0.05) , respectively, lysine metabolism, amino sugar metabolism, and nucleotide sugar metabolism. Conclusion: The metabonomics method can well reflect the changes in the metabolome of urine samples in the occupational population after the combined exposure of benzene, toluene, and xylene, which will help us better evaluate the risk of combined exposure of benzene, toluene, and xylene and prevent and control their health risks.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
xxx完成签到,获得积分10
2秒前
8秒前
Green完成签到,获得积分10
10秒前
斐嘿嘿发布了新的文献求助10
11秒前
谢丹完成签到 ,获得积分10
12秒前
寒冷的完成签到,获得积分10
16秒前
文武完成签到 ,获得积分10
20秒前
zlf完成签到,获得积分10
21秒前
43秒前
43秒前
香蕉觅云应助科研通管家采纳,获得10
43秒前
57秒前
林宥嘉完成签到 ,获得积分10
1分钟前
老夫子完成签到,获得积分10
1分钟前
kenti2023完成签到 ,获得积分10
1分钟前
1分钟前
YYYCCCCC发布了新的文献求助10
1分钟前
1分钟前
11发布了新的文献求助10
1分钟前
CipherSage应助miles采纳,获得10
1分钟前
周游完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
huihongzeng发布了新的文献求助10
1分钟前
Judy完成签到 ,获得积分10
1分钟前
利物鸟贝拉完成签到,获得积分10
1分钟前
1分钟前
Esperanza完成签到,获得积分10
1分钟前
miles发布了新的文献求助10
2分钟前
2分钟前
鹿茸与共发布了新的文献求助10
2分钟前
2分钟前
jianghs完成签到,获得积分10
2分钟前
科目三应助11采纳,获得10
2分钟前
jianghs发布了新的文献求助10
2分钟前
2分钟前
feifei完成签到,获得积分10
2分钟前
feifei发布了新的文献求助10
2分钟前
福娃哇完成签到 ,获得积分10
2分钟前
科研通AI2S应助科研通管家采纳,获得10
2分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990015
求助须知:如何正确求助?哪些是违规求助? 3532077
关于积分的说明 11256227
捐赠科研通 3270933
什么是DOI,文献DOI怎么找? 1805139
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228