血管生成
结直肠癌
癌症研究
医学
肿瘤微环境
转移
癌症
新生血管
肿瘤进展
血管内皮生长因子
癌细胞
内科学
炎症
肿瘤科
作者
Masatsune Shibutani,Shigetomi Nakao,Kiyoshi Maeda,Hisashi Nagahara,Shinichiro Kashiwagi,Kosei Hirakawa,Masaichi Ohira
出处
期刊:Anticancer Research
[Anticancer Research USA Inc.]
日期:2021-04-22
卷期号:41 (9): 4447-4453
被引量:1
标识
DOI:10.21873/anticanres.15253
摘要
Background/aim The tumor microenvironment plays an important role in tumor progression. Tumor-associated macrophages (TAMs) have been reported to promote proliferation, invasion, metastasis, angiogenesis, and immunosuppression. Furthermore, angiogenesis has been reported to induce chemoresistance due to the inefficient distribution of drugs to cancer cells. However, the impact of TAMs on chemoresistance via angiogenesis in colorectal cancer (CRC) remains unclear. The aim of the study was to evaluate the impact of TAMs on the chemotherapeutic outcome in CRC. Patients and methods We enrolled 54 patients who underwent chemotherapy for unresectable metastatic CRC after resection of the primary tumor. We evaluated the density of TAMs and the degree of angiogenesis by immunohistochemistry and then explored the correlation between the density of TAMs and chemotherapeutic outcome. Furthermore, we assessed any correlation between the density of TAMs and that of neovascularity. Results The high-TAMs group had a significantly worse progression-free survival (p=0.0006) and a poorer response rate (p=0.0274) than the low-TAMs group. In addition, a positive correlation was observed between the density of TAMs and the degree of neovascularity (r=0.665, p=0.0004). Conclusion TAMs were shown to promote chemoresistance via angiogenesis in CRC.
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