抑制性突触后电位
免疫系统
神经科学
细胞生物学
机制(生物学)
树突状细胞
癌症
癌细胞
生物
化学
免疫学
遗传学
认识论
哲学
作者
Joanne K. Gardner,Cyril Mamotte,Connie Jackaman,Delia J. Nelson
标识
DOI:10.1016/j.arr.2017.07.002
摘要
Dendritic cells (DCs) undergo continuous changes throughout life, and there is evidence that elderly DCs have a reduced capacity to stimulate T cells, which may contribute to impaired anti-tumour immune responses in elderly people with cancer. Changes in checkpoint inhibitory molecules/pathways during aging may be one mechanism that impairs the ability of elderly DCs to activate T cells. However, little is currently known regarding the combined effects of aging and cancer on DC and T cell inhibitory molecules/pathways. In this review, we discuss our current understanding of the influence of aging and cancer on key DC and T cell inhibitory molecules/pathways, the potential underlying cellular and molecular mechanisms contributing to their modulation, and the possibility of therapeutically targeting inhibitory molecules in elderly cancer patients.
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