Structural and functional deficits and couplings in severe and moderate OCD

库尼乌斯 楔前 舌回 顶叶上小叶 心理学 顶叶下小叶 枕叶 额中回 基于体素的形态计量学 神经科学 颞下回 听力学 医学 磁共振成像 颞叶 功能磁共振成像 白质 放射科 癫痫
作者
Yinhuan Xu,Ruiping Zheng,Huirong Guo,Yarui Wei,Baohong Wen,Shufan Dai,Shaoqiang Han,Jingliang Cheng,Yan Zhang
出处
期刊:Journal of Psychiatric Research [Elsevier BV]
卷期号:160: 240-247 被引量:8
标识
DOI:10.1016/j.jpsychires.2023.02.022
摘要

Changes in gray matter volume and functional connections have been frequently observed in patients with obsessive compulsive disorder. However, different grouping may cause diverse volume alterations and could draw more adverse conclusions about the pathophysiology of obsessive compulsive disorder(OCD). Most of them preferred to divide subjects into patients and healthy controls, rather than a detailed subgroup. Moreover, multimodal neuroimaging studies about structural-functional defects and couplings are rather rare. Our aim was to explore gray matter volume(GMV) and functional networks abnormalities induced by structural deficits based on severity of Yale-Brown Obsessive Compulsive Scale(Y-BOCS) symptom including OCD patients with severe(S-OCD, n = 31) and moderate symptoms(M-OCD, n = 42) and healthy controls (HCs, n = 54); Voxel-based morphometry(VBM) method was used to detect GMV differences among three groups, then used as masks according to one-way analysis of variance(ANOVA) results for the subsequent resting-state functional connectivity(rs-FC) analysis. Besides, correlation and subgroup analysis were performed to detect the potential roles of structural deficits between every two groups. ANOVA analysis showed that both S-OCD and M-OCD had increased volume in anterior cingulate cortex(ACC), left precuneus(L-Pre) and paracentral lobule(PCL), postcentral gyrus, left inferior occipital gyrus(L-IOG) and right superior occipital gyrus(R-SOG) and bilateral cuneus, middle occipital gyrus(MOG), and calcarine. Additionally, increased connections between Pre and angular gyrus(AG) and inferior parietal lobule(IPL) have been found. Moreover, connections between the left cuneus and lingual gyrus, between IOG and left lingual gyrus, fusiform and between L-MOG and cerebellum were also included. Subgroup analysis showed that decreased GMV in left caudate was negatively correlated with compulsion and total score in patients with moderate symptom compared to HCs. Our findings indicated that altered GMV in occipital-related regions, Pre, ACC and PCL and the disrupted FC networks including MOG-cerebellum and Pre-AG and IPL. Moreover, subgroup GMV analysis furtherly revealed negative associations between GMV changes and Y-BOCS symptom, offering preparatory proof for the involvement of structural and functional deficits in cortical-subcortical circuitry. Thus, they could provide insights into the neurobiological basis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
kcmat发布了新的文献求助10
1秒前
hh完成签到,获得积分10
2秒前
Philadelphus发布了新的文献求助10
3秒前
einuo完成签到,获得积分10
3秒前
AKYDXS完成签到,获得积分10
6秒前
昏睡的蟠桃应助Llllll采纳,获得200
6秒前
科研通AI2S应助hao采纳,获得10
6秒前
7秒前
7秒前
香蕉觅云应助阿湫采纳,获得10
8秒前
星辰大海应助星辰采纳,获得10
8秒前
阿卡宁完成签到,获得积分10
8秒前
lzw完成签到 ,获得积分10
8秒前
沉静烧仙草完成签到,获得积分20
9秒前
烟花应助嘉嘉琦采纳,获得10
9秒前
隐形曼青应助科研通管家采纳,获得10
9秒前
Hello应助科研通管家采纳,获得10
10秒前
Ava应助科研通管家采纳,获得10
10秒前
上官若男应助科研通管家采纳,获得10
10秒前
10秒前
赘婿应助科研通管家采纳,获得10
10秒前
烟花应助科研通管家采纳,获得10
10秒前
FashionBoy应助科研通管家采纳,获得10
10秒前
英俊的铭应助科研通管家采纳,获得10
10秒前
在水一方应助科研通管家采纳,获得10
10秒前
accepted应助科研通管家采纳,获得10
10秒前
脑洞疼应助科研通管家采纳,获得10
10秒前
10秒前
cdh1994应助kcmat采纳,获得10
10秒前
我是老大应助科研通管家采纳,获得10
10秒前
乐乐应助科研通管家采纳,获得10
10秒前
FashionBoy应助科研通管家采纳,获得10
10秒前
10秒前
上官若男应助科研通管家采纳,获得10
10秒前
10秒前
10秒前
10秒前
我是老大应助科研通管家采纳,获得30
10秒前
脑洞疼应助科研通管家采纳,获得20
11秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048