普罗布考
疾病
非酒精性脂肪肝
医学
脂肪肝
机制(生物学)
发病机制
药物开发
药品
药理学
生物信息学
胆固醇
内科学
生物
哲学
认识论
作者
Ke-qian Chen,Bo-yi Ke,Lu Cheng,Meng-ting Guan,Zongbao Wang,Shuzhi Wang
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2023-03-27
卷期号:23 (19): 1905-1911
被引量:1
标识
DOI:10.2174/1389557523666230324092842
摘要
With the development of the social economy over the last 30 years, non-alcoholic fatty liver disease (NAFLD) is affected by unhealthy living habits and eating styles and has gradually become an increasingly serious public health problem. It is very important to investigate the pathogenesis and treatment of NAFLD for the development of human health. Probucol is an antioxidant with a bis-phenol structure. Although probucol is a clinically used cholesterol-lowering and antiatherosclerosis drug, its mechanism has not been elucidated in detail. This paper reviews the chemical structure, pharmacokinetics and pharmacological research of probucol. Meanwhile, this paper reviews the mechanism of probucol in NAFLD. We also analyzed and summarized the experimental models and clinical trials of probucol in NAFLD. Although current therapeutic strategies for NAFLD are not effective, we hope that through further research on probucol, we will be able to find suitable treatments to solve this problem in the future.
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