Multi-omics integrated circulating cell-free DNA genomic signatures enhanced the diagnostic performance of early-stage lung cancer and postoperative minimal residual disease

液体活检 医学 阶段(地层学) 内科学 肿瘤科 人口 肺癌 微小残留病 癌症 生物 古生物学 环境卫生 白血病
作者
Yun Li,Guanchao Jiang,Wendy Wu,Hao Yang,Yichen Jin,Manqi Wu,Wenjie Liu,Airong Yang,Olga Chervova,Sujie Zhang,Lu Zheng,Xueying Zhang,Fengxia Du,Nnennaya Kanu,Lin Wu,Fan Yang,Jun Wang,Kezhong Chen
出处
期刊:EBioMedicine [Elsevier BV]
卷期号:91: 104553-104553 被引量:29
标识
DOI:10.1016/j.ebiom.2023.104553
摘要

Liquid biopsy is a promising non-invasive alternative for cancer screening and minimal residual disease (MRD) detection, although there are some concerns regarding its clinical applications. We aimed to develop an accurate detection platform based on liquid biopsy for both cancer screening and MRD detection in patients with lung cancer (LC), which is also applicable to clinical use.We applied a modified whole-genome sequencing (WGS) -based High-performance Infrastructure For MultIomics (HIFI) method for LC screening and postoperative MRD detection by combining the hyper-co-methylated read approach and the circulating single-molecule amplification and resequencing technology (cSMART2.0).For early screening of LC, the LC score model was constructed using the support vector machine, which showed sensitivity (51.8%) at high specificity (96.3%) and achieved an AUC of 0.912 in the validation set prospectively enrolled from multiple centers. The screening model achieved detection efficiency with an AUC of 0.906 in patients with lung adenocarcinoma and outperformed other clinical models in solid nodule cohort. When applied the HIFI model to real social population, a negative predictive value (NPV) of 99.92% was achieved in Chinese population. Additionally, the MRD detection rate improved significantly by combining results from WGS and cSMART2.0, with sensitivity of 73.7% at specificity of 97.3%.In conclusion, the HIFI method is promising for diagnosis and postoperative monitoring of LC.This study was supported by CAMS Innovation Fund for Medical Sciences, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, Beijing Natural Science Foundation and Peking University People's Hospital.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1GE完成签到,获得积分10
2秒前
小马甲应助我不吃胡萝卜采纳,获得10
2秒前
雅哈完成签到,获得积分10
2秒前
3秒前
4秒前
5秒前
6秒前
安澜发布了新的文献求助10
6秒前
王佳亮发布了新的文献求助10
7秒前
7秒前
我不吃胡萝卜完成签到,获得积分10
10秒前
赘婿应助Huang_being采纳,获得10
10秒前
颜云尔发布了新的文献求助10
11秒前
凌辰发布了新的文献求助10
11秒前
13秒前
丹丹发布了新的文献求助10
14秒前
天天快乐应助Melody采纳,获得10
14秒前
Jasper应助正直凌文采纳,获得10
14秒前
坚强枫发布了新的文献求助10
15秒前
量子星尘发布了新的文献求助10
15秒前
16秒前
林林完成签到 ,获得积分10
17秒前
hhhh发布了新的文献求助30
18秒前
19秒前
壮观采文完成签到,获得积分10
21秒前
KIORking发布了新的文献求助10
22秒前
23秒前
张建发布了新的文献求助10
24秒前
Hello应助丹丹采纳,获得10
24秒前
30秒前
KIORking完成签到,获得积分10
31秒前
31秒前
安澜完成签到,获得积分20
31秒前
dsfsd发布了新的文献求助10
32秒前
32秒前
34秒前
34秒前
张涛发布了新的文献求助10
35秒前
酷波er应助Lee采纳,获得10
37秒前
呆瓜完成签到,获得积分10
39秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988975
求助须知:如何正确求助?哪些是违规求助? 3531316
关于积分的说明 11253424
捐赠科研通 3269917
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882063
科研通“疑难数据库(出版商)”最低求助积分说明 809068