神经科学
神经炎症
中枢神经系统
星形胶质细胞
睡眠(系统调用)
疾病
神经系统
生物
心理学
医学
病理
计算机科学
操作系统
作者
Sergey V. Gudkov,Dmitriy E. Burmistrov,Elena Kondakova,Ruslan M. Sarimov,Roman S. Yarkov,Claudio Franceschi,Maria V. Vedunova
标识
DOI:10.1016/j.arr.2022.101775
摘要
Understanding the role of astrocytes in the central nervous system has changed dramatically over the last decade. The accumulating findings indicate that glial cells are involved not only in the maintenance of metabolic and ionic homeostasis and in the implementation of trophic functions but also in cognitive functions and information processing in the brain. Currently, there are some controversies regarding the role of astrocytes in complex processes such as aging of the nervous system and the pathogenesis of age-related neurodegenerative diseases. Many findings confirm the important functional role of astrocytes in age-related brain changes, including sleep disturbance and the development of neurodegenerative diseases and particularly Alzheimer's disease. Until recent years, neurobiological research has focused mainly on neuron-glial interactions, in which individual astrocytes locally modulate neuronal activity and communication between neurons. The review considers the role of astrocytes in the physiology of sleep and as an important "player" in the development of neurodegenerative diseases. In addition, the features of the astrocytic network reorganization during aging are discussed.
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