免疫疗法
调节器
免疫
获得性免疫系统
疾病
炎症
生物
医学
平衡
先天免疫系统
主调节器
机制(生物学)
神经科学
细胞生物学
免疫学
免疫系统
转录因子
基因
遗传学
哲学
认识论
病理
作者
Luxia Xu,Feiyan Pan,Zhigang Guo
出处
期刊:Journal of Immunology
[The American Association of Immunologists]
日期:2024-03-01
卷期号:212 (5): 755-763
标识
DOI:10.4049/jimmunol.2300433
摘要
Abstract TNF-α–induced protein 8–like 2 (TIPE2 or TNFAIP8L2) is a recently discovered negative regulator of innate and adaptive immunity. TIPE2 is expressed in a wide range of tissues, both immune and nonimmune, and is implicated in the maintenance of immune homeostasis within the immune system. Furthermore, TIPE2 has been shown to play a pivotal role in the regulation of inflammation and the development of tumor. This review focuses on the structural characteristics, expression patterns, and functional roles of TIPE proteins, with a particular emphasis on the role and underlying mechanisms of TIPE2 in immune regulation and its involvement in different diseases. However, the current body of evidence is still limited in providing a comprehensive understanding of the complex role of TIPE2 in the human body, warranting further investigation to elucidate the possible mechanisms and functions of TIPE2 in diverse disease contexts.
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