败血症
基因敲除
旁分泌信号
肺
脂多糖
血管通透性
生物
免疫学
转录因子
下调和上调
癌症研究
细胞生物学
医学
基因
内科学
内分泌学
遗传学
受体
作者
Junxia Li,Miaomiao Tan,Tian Yang,Qingyuan Huang,Fabo Shan
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2023-12-04
卷期号:326 (1): C304-C316
被引量:1
标识
DOI:10.1152/ajpcell.00431.2023
摘要
This article addresses the role of the alveolar epithelial-secreted protein isthmin1 on the exacerbation of pulmonary vascular permeability in sepsis and identified nuclear factor CCAAT/enhancer binding protein (C/EBP)β as a new regulator of isthmin1 gene transcription. Targeting the C/EBPβ-isthmin1 regulatory axis on the alveolar side would be of great value in the treatment of pulmonary vascular leakage and lung injury induced by sepsis.
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