Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

自愈水凝胶 超分子化学 环糊精 材料科学 纳米技术 高分子化学 化学 有机化学 分子
作者
Yuqi Zhao,Zhifeng Zheng,Cui‐Yun Yu,Hua Wei
出处
期刊:Journal of Materials Chemistry B [The Royal Society of Chemistry]
卷期号:12 (1): 39-63 被引量:13
标识
DOI:10.1039/d3tb02101g
摘要

Cyclodextrin (CD)-based supramolecular hydrogels are polymer network systems with the ability to rapidly form reversible three-dimensional porous structures through multiple cross-linking methods, offering potential applications in drug delivery. Although CD-based supramolecular hydrogels have been increasingly used in a wide range of applications in recent years, a comprehensive description of their structure, mechanical property modulation, drug loading, delivery, and applications in biomedical fields from a cross-linking perspective is lacking. To provide a comprehensive overview of CD-based supramolecular hydrogels, this review systematically describes their design, regulation of mechanical properties, modes of drug loading and release, and their roles in various biomedical fields, particularly oncology, wound dressing, bone repair, and myocardial tissue engineering. Additionally, this review provides a rational discussion on the current challenges and prospects of CD-based supramolecular hydrogels, which can provide ideas for the rapid development of CD-based hydrogels and foster their translation from the laboratory to clinical medicine.
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