Cooperation between Cu+ and Cu2+ species in CuCoAl layered double hydroxide and substrate promoting effect afford a really simple protocol for the efficient synthesis of quinazolines

In this study, a really simple and efficient catalytic protocol for the construction of quinazolines from alcohol and diamine has been developed based on CuCoAl layered double hydroxide (CuCoAl-LDH). The developed CuCoAl-LDH catalyst could accelerate the cascade reactions without any additives and tolerate various alcohols with satisfactory yields. Cooperation between the Cu