Particulate matter of air pollution may increase risk of kidney failure in IgA nephropathy

医学 肾脏疾病 肾功能 肾病 危险系数 内科学 人口 胃肠病学 肌酐 置信区间 内分泌学 生理学 糖尿病 环境卫生
作者
Chengwen Luo,Yan Ouyang,Sufang Shi,Guisen Li,Zhanzheng Zhao,Huimin Luo,Feifei Xu,Leping Shao,Zijin Chen,Shuwen Yu,Yuanmeng Jin,Jing Xu,Wen Du,Zhengying Fang,Hafiz Muhammad Jafar Hussain,Wen Zhang,Weiming Wang,Yidan Cui,Hong Zhang,Nan Chen
出处
期刊:Kidney International [Elsevier BV]
卷期号:102 (6): 1382-1391 被引量:21
标识
DOI:10.1016/j.kint.2022.08.020
摘要

IgA nephropathy (IgAN) is characterized by deposition of galactose-deficient IgA1 (Gd-IgA1) in glomerular mesangium associated with mucosal immune disorders. Since environmental pollution has been associated with the progression of chronic kidney disease in the general population, we specifically investigated the influence of exposure to fine particulate matter less than 2.5 μm in diameter (PM2.5) on IgAN progression. Patients with biopsy-proven primary IgAN were recruited from seven Chinese kidney centers. PM2.5 exposure from 1998 to 2016 was derived from satellite aerosol optical depth data and a total of 1,979 patients with IgAN, including 994 males were enrolled. The PM2.5 exposure levels for patients from different provinces varied but, in general, the PM2.5 exposure levels among patients from the north were higher than those among patients from the south. The severity of PM2.5 exposure in different regions was correlated with regional kidney failure burden. In addition, each 10 μg/m3 increase in annual average concentration of PM2.5 exposure before study entry (Hazard Ratio, 1.14; 95% confidence interval, 1.06-1.22) or time-varying PM2.5 exposure after study entry (1.10; 1.01-1.18) were associated with increased kidney failure risk after adjustment for age, gender, estimated glomerular filtration rate, urine protein, uric acid, hemoglobin, mean arterial pressure, Oxford classification, glucocorticoid and renin-angiotensin system blocker therapy. The associations were robust when the time period, risk factors of cardiovascular diseases or city size were further adjusted on the basis of the above model. Thus, our results suggest that PM2.5 is an independent risk factor for kidney failure in patients with IgAN, but these findings will require validation in more diverse populations and other geographic regions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
刚刚
科研通AI2S应助七星茶采纳,获得10
刚刚
丸子完成签到,获得积分20
1秒前
舒庆春发布了新的文献求助10
1秒前
2秒前
2秒前
healer完成签到,获得积分10
2秒前
芋倪啵啵完成签到 ,获得积分10
3秒前
3秒前
3秒前
crucible完成签到,获得积分10
3秒前
哈哈完成签到,获得积分10
4秒前
充电宝应助HXT采纳,获得10
4秒前
wfy发布了新的文献求助20
4秒前
正直花生发布了新的文献求助10
5秒前
精明思松发布了新的文献求助10
6秒前
友好旭尧发布了新的文献求助10
7秒前
UUU发布了新的文献求助10
7秒前
qiuqiu完成签到,获得积分10
7秒前
KK发布了新的文献求助30
7秒前
核桃小小苏完成签到,获得积分10
8秒前
8秒前
Owen应助yangyangyang采纳,获得10
9秒前
healer发布了新的文献求助10
9秒前
bjbbh完成签到,获得积分10
10秒前
叶音竹发布了新的文献求助10
11秒前
12秒前
youxueting发布了新的文献求助10
14秒前
正直花生完成签到,获得积分10
14秒前
CR7应助丸子采纳,获得20
15秒前
陈成应助123采纳,获得10
15秒前
嘿1111完成签到,获得积分10
15秒前
顾矜应助江南神采纳,获得10
15秒前
猪猪发布了新的文献求助20
16秒前
高兴微笑发布了新的文献求助10
16秒前
16秒前
田様应助chen采纳,获得10
17秒前
17秒前
小西瓜完成签到,获得积分10
17秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
北师大毕业论文 基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 390
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 360
Atlas of Interventional Pain Management 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4011029
求助须知:如何正确求助?哪些是违规求助? 3550660
关于积分的说明 11306082
捐赠科研通 3284968
什么是DOI,文献DOI怎么找? 1810924
邀请新用户注册赠送积分活动 886594
科研通“疑难数据库(出版商)”最低求助积分说明 811526