DNA甲基化
甲基化
碘
CpG站点
人口
医学
内科学
化学
生理学
基因
基因表达
生物化学
环境卫生
有机化学
作者
Hongmei Shen,Jinjin Liu,Yun Chen,Bingxuan Ren,Zheng Zhou,Meihui Jin,Lingbo Wang,Yu He,Li Fan,Baoxiang Li,Mingyu Du
标识
DOI:10.1080/09603123.2023.2280148
摘要
Our study aimed to identify and verify G protein-related methylated genes in AIT patients, while also investigate those genes in AIT patients exposed to iodine in different water iodine areas. Different areas were classified by median water iodine (MWI) concentrations: Iodine-Fortified Areas (IFA, MWI<10µg/L), Iodine-Adequate Areas (IAA, 40≤MWI≤100 µg/L), and Iodine-Excessive Areas (IEA, MWI>100 µg/L). We studied 176 AIT cases and 176 controls, with 89, 40, and 47 pairs in IFA, IAA, and IEA, respectively. Using the Illumina Human Methylation 850k BeadChip, we identified candidate methylated genes. MethylTargetTM and QRT-PCR validated DNA methylation and mRNA expression. Results showed hypomethylation and high expression of RAB8A and RAP1A in all 176 AIT cases. RAB8A's CpG sites were mainly hypomethylated in IFA and IEA, while RAP1A's sites were primarily hypomethylated in IEA. This study underscores how water iodine exposure may influence RAB8A and RAP1A methylation in AIT.
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