吉西他滨
紫杉醇
胰腺癌
药物输送
材料科学
乳腺癌
微加工
控制释放
阿霉素
纳米技术
癌症
生物医学工程
化疗
医学
内科学
病理
替代医学
制作
作者
Lihuang Wu,Junhua Li,Yuqi Wang,Xinyue Zhao,Yiyan He,Hongli Mao,Wenbo Tang,Rong Liu,Kui Luo,Zhongwei Gu
标识
DOI:10.1002/adma.202305529
摘要
Drug treatment is required for both resectable and unresectable cancers to strive for any meaningful improvement in patient outcomes. However, the clinical benefit of receiving conventional systemic administrations is often less than satisfactory. Drug delivery systems are preferable substitutes but still fail to meet diverse clinical demands due to the difficulty in programming drug release profiles. Herein, a microfabrication concept, termed "Hierarchical Multiple Polymers Immobilization" (HMPI), is introduced and biodegradable-polymer-based hierarchical microdevices (HMDs) that can pre-program any desired controlled release profiles are engineered. Based on the first-line medication of pancreatic and breast cancer, controlled release of single gemcitabine and the doxorubicin/paclitaxel combination in situ for multiple courses is implemented, respectively. Preclinical models of postsurgical pancreatic, postsurgical breast, and unresectable breast cancer are established, and the designed HMDs are demonstrated as well-tolerable and effective treatments for inhibiting tumor growth, recurrence, and metastasis. The proposed HMPI strategy allows the creation of tailorable and high-resolution hierarchical microstructures for pre-programming controlled release according to clinical medication schedules, which may provide promising alternative treatments for postsurgical and unresectable tumor control.
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