耐火期
医学
血小板
血小板输注
人类白细胞抗原
免疫学
耐火材料(行星科学)
造血
重症监护医学
干细胞
内科学
抗原
生物
天体生物学
遗传学
作者
Sandhya R. Panch,Li Guo,Ralph Vassallo
出处
期刊:Blood Reviews
[Elsevier]
日期:2023-10-02
卷期号:62: 101135-101135
被引量:5
标识
DOI:10.1016/j.blre.2023.101135
摘要
Platelet transfusion refractoriness due to HLA alloimmunization presents a significant medical problem, particularly among multiply transfused patients with hematologic malignancies and those undergoing hematopoietic stem cell transplants. HLA compatible platelet transfusions also impose significant financial burden on these patients. Recently, several novel mechanisms have been described in the development of HLA alloimmunization and platelet transfusion refractoriness. We review the history of platelet transfusions and mechanisms of HLA-sensitization and transfusion refractoriness. We also summarize advances in the diagnosis and treatment of platelet transfusion refractoriness due to HLA alloimmunization.
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