封锁
痛苦
CD40
免疫系统
免疫检查点
效应器
肿瘤微环境
免疫疗法
免疫学
生物
癌症研究
受体
细胞毒性T细胞
体外
遗传学
政治
政治学
法学
作者
Richard C. Wu,Jason J. Luke
标识
DOI：10.1158/1078-0432.ccr-23-2437
摘要
Summary In this CCR Translations, we discuss the therapeutic potential of CD40 agonism, which stimulates antigen-presenting cells (APC) to activate effector T and NK cells. CD40 agonism may lead to development of an interferon-activated, T cell–inflamed tumor microenvironment and has the potential to facilitate long-term response with immune checkpoint blockade. See related article by Weiss et al., p. 74
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(2025-6-4)
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