化学
钯
催化作用
级联
甲基化
组合化学
药物化学
立体化学
有机化学
生物化学
DNA
色谱法
作者
Wei Feng,Yanghui Zhang
标识
DOI:10.1021/acs.orglett.4c03315
摘要
Transition metal-catalyzed C–H methylation represents a straightforward approach for introducing methyl groups into organic molecules. Herein, we report a palladium-catalyzed alkene-relayed remote C–H methylation reaction that utilizes dimethyl carbonate as the methylation reagent. The aryl groups distal to a bromo group were dimethylated via C–H activation, leading to the formation of spirooxindoles as the final products through C(sp3)–H activation and C(sp3)–C(sp3) coupling. This cascade process involves the formation of four C–C bonds and the activation of three C–H bonds. The reaction not only provides a new approach to C–H methylation but also offers a novel method for constructing spirooxindole skeletons by merging skeleton construction and methylation into a single step.
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