生物
非编码RNA
小RNA
编码
计算生物学
癌症
核糖核酸
基因
遗传学
生物信息学
作者
Jiayuan Huang,Ping Yang,Wei Pan,Fan Wu,Jianhua Qiu,Zhongliang Ma
出处
期刊:Gene
[Elsevier]
日期:2024-11-01
卷期号:928: 148817-148817
标识
DOI:10.1016/j.gene.2024.148817
摘要
It was previously thought that ncRNA could not encode polypeptides, but recent reports have challenged this notion. As research into ncRNA progresses, it is increasingly clear that it serves roles beyond traditional mechanisms, playing significant regulatory roles in various diseases, notably cancer, which is responsible for 70% of human deaths. Numerous studies have highlighted the diverse regulatory mechanisms of ncRNA that are pivotal in cancer initiation and progression. The role of ncRNA-encoded polypeptides in cancer regulation has gained prominence. This article explores the newly identified regulatory functions of these polypeptides in three types of ncRNA-lncRNA, pri-miRNA, and circRNA. These polypeptides can interact with proteins, influence signaling pathways, enhance miRNA stability, and regulate cancer progression, malignancy, resistance, and other clinical challenges. Furthermore, we discuss the evolutionary significance of these polypeptides in the transition from RNA to protein, examining their emergence and conservation throughout evolution.
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