医学
成纤维细胞活化蛋白
成纤维细胞
癌症研究
计算生物学
药理学
内科学
生物化学
癌症
体外
生物
化学
作者
Richard P. Baum,Emil Novruzov,Tianzhi Zhao,Lukas Greifenstein,Vivianne Jakobsson,Elisabetta Perrone,A. Mishra,Aleksandr Eismant,Kriti Ghai,O. Klein,Bastian Jaeschke,Daniel Benz-Zils,Jens Cardinale,Yuriko Mori,Frederik L. Giesel,Jingjing Zhang
标识
DOI:10.1053/j.semnuclmed.2024.05.010
摘要
The advancement of theranostics, which combines therapeutic and diagnostic capabilities in oncology, has significantly impacted cancer management. This review explores fibroblast activation protein (FAP) expression in the tumor microenvironment (TME) and its association with various malignancies, highlighting its potential as a theranostic marker for PET/CT imaging using FAP-targeted tracers and for FAP-targeted radiopharmaceutical therapy. We examine the development and clinical applications of FAP inhibitors (FAPIs) and peptides, providing insights into their diagnostic accuracy, initial therapeutic efficacy, and clinical impact across diverse cancer types, as well as the synthesis of novel FAP-targeted ligands. This review aims to showcase the promising outcomes and challenges in integrating FAP-targeted approaches into cancer management.
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