68Ga-DOTATATE Uptake in Pancreatic Ductal Adenocarcinoma

Abstract We present a case of pancreatic ductal adenocarcinoma showing increased 68 Ga-DOTATATE uptake mimicking neuroendocrine tumor on PET/CT. Immunohistochemical analyses of the resected tumor showed the tumor cells were negative for somatostatin receptor subtype 2. The nonneoplastic islets scattered throughout the tumor were positive for somatostatin receptor subtype 2, which may be responsible for the increased 68 Ga-DOTATATE uptake. This case indicates that pancreatic ductal adenocarcinoma should be included in the differential diagnosis of the pancreatic lesions showing increased 68 Ga-DOTATATE uptake.