机制(生物学)
生物
拥挤
细胞质
细胞生物学
计算生物学
化学
神经科学
物理
量子力学
作者
Zhenyu Wang,Qiuhua Yang,Shouxin Zhang,Lu Yang,Yichuan Wang,Yajie Pan,Yuping Qiu,Yongfan Men,Wei Yan,Zhina Xiao,Ruixue Sun,Wenyang Li,Hongda Huang,Hongwei Guo
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-10-31
卷期号:386 (6721)
标识
DOI:10.1126/science.adk9067
摘要
Plants are frequently challenged by osmotic stresses. How plant cells sense environmental osmolarity changes is not fully understood. We report that Arabidopsis Decapping 5 (DCP5) functions as a multifunctional cytoplasmic osmosensor that senses and responds to extracellular hyperosmolarity. DCP5 harbors a plant-specific intramolecular crowding sensor (ICS) that undergoes conformational change and drives phase separation in response to osmotically intensified molecular crowding. Upon hyperosmolarity exposure, DCP5 rapidly and reversibly assembles to DCP5-enriched osmotic stress granules (DOSGs), which sequestrate plenty of mRNA and regulatory proteins, and thus adaptively reprograms both the translatome and transcriptome to facilitate plant osmotic stress adaptation. Our findings uncover a cytoplasmic osmosensing mechanism mediated by DCP5 with plant-specific molecular crowding sensitivity and suggest a stress sensory function for hyperosmotically induced stress granules.
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