核梭杆菌
牙周炎
牙龈卟啉单胞菌
微生物学
炎症
牙周组织
牙槽
毒力
牙周纤维
生物
细菌外膜
免疫学
化学
医学
牙科
基因
生物化学
大肠杆菌
作者
Li Zhang,Demao Zhang,Chengcheng Liu,Boyu Tang,Yujia Cui,Daimo Guo,Mengmeng Duan,Ying Tu,Huiling Zheng,Xinjie Ning,Yang Liu,Haoran Chen,Minglei Huang,Zhixing Niu,Yanfang Zhao,Xiaoheng Liu,Jing Xie
标识
DOI:10.1002/advs.202400882
摘要
Abstract The virulent bacteria‐induced host immune response dominates the occurrence and progression of periodontal diseases because of the roles of individual virulence factors from these pathogens in the initiation and spread of inflammation. Outer membrane vesicles (OMVs) as a pathogenic entity have recently attracted great attention as messenger bridges between bacteria and host tissues. Herein, the novel role of OMVs derived from Fusobacterium nucleatum in the occurrence of periodontitis is dissected. In a rat periodontitis model, it is found that OMVs derived from F. nucleatum caused deterioration of periodontitis by enhancing inflammation of the periodontium and absorption of alveolar bone, which is almost equivalent to the effect of F. nucleatum itself. Furthermore, that OMVs can independently induce periodontitis is shown. The pathogenicity of OMVs is attributed to multiple pathogenic components identified by omics. After entering human periodontal ligament stem cells (hPDLSCs) by endocytosis, OMVs activated NLRP3 inflammasomes and impaired the mineralization of hPDLSCs through NF‐κB (p65) signaling, leading to the final injury of the periodontium and damage of alveolar bone in periodontitis. These results provide a new understanding of OMVs derived from pathogens and cues for the prevention of periodontitis.
科研通智能强力驱动
Strongly Powered by AbleSci AI