Surface-Enhanced Raman Spectroscopy for Nitrite Detection

Nitrite is an important chemical intermediate in the nitrogen cycle and is ubiquitously present in environmental and biological systems as a metabolite or additive in the agricultural and food industries. However, nitrite can also be toxic in excessive concentrations. As such, the development of quick, sensitive, and portable assays for its measurement is desirable. In this review, we summarize the working principles and applications of surface-enhanced Raman spectroscopy (SERS) as a rapid, portable, and ultrasensitive method for nitrite detection and showcase its applicability in various water, food, and biological samples. The challenges and opportunities for future developments are also discussed.