Iontophoresis for the cutaneous delivery of nanoentraped drugs

离子导入 药物输送 药理学 纳米技术 医学 材料科学 放射科
作者
Jayanaraian F. M. Andrade,Marcílio Cunha‐Filho,Guilherme M. Gelfuso,Taís Gratieri
出处
期刊:Expert Opinion on Drug Delivery [Informa]
卷期号:20 (6): 785-798 被引量:7
标识
DOI:10.1080/17425247.2023.2209719
摘要

The skin is an attractive route for drug delivery. However, the stratum corneum is a critical limiting barrier for drug permeation. Nanoentrapment is a way to enhance cutaneous drug delivery, by diverse mechanisms, with a notable trend of nanoparticles accumulating into the hair follicles when topically applied. Iontophoresis is yet another way of increasing drug transport by applying a mild electrical field that preferentially passes through the hair follicles, for being the pathway of lower resistance. So, iontophoresis application to nanocarriers could further increase actives accumulation into the hair follicles, impacting cutaneous drug delivery.In this review, the authors aimed to discuss the main factors impacting iontophoretic skin transport when combining nanocarriers with iontophoresis. We further provide an overview of the conditions in which this combination has been studied, the characteristics of nanosystems employed, and hypothesize why the association has succeeded or failed to enhance drug permeation.Nanocarriers and iontophoresis association can be promising to enhance cutaneous drug delivery. For better results, the electroosmotic contribution to the iontophoretic transport, mainly of negatively charged nanocarriers, charge density, formulation pH, and skin models should be considered. Moreover, the transfollicular pathway should be considered, especially when designing the nanocarriers.
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