Hostile bile limits anti-cancer immunity

Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8+ T cell responses via dysregulation of calcium efflux. Various microbial metabolites promote cell transformation. In this issue of Immunity, Cong et al. show that deoxycholic acid (DCA), a microbial metabolite of bile, promotes tumor growth by suppressing antitumor CD8+ T cell responses via dysregulation of calcium efflux. Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functionsCong et al.ImmunityMarch 12, 2024In BriefOur understanding of the impact of microbial metabolites on anti-tumor immunity is incomplete. Cong et al. show aberrant elevation of the microbiota-derived secondary bile acid, deoxycholic acid, in colorectal cancer patients. Deoxycholic acid suppresses cytotoxic CD8+ T cell effector functions by impairing intracellular calcium accumulation, subsequently promoting colorectal tumor growth. Full-Text PDF