产热
白色脂肪组织
内分泌学
内科学
肠道菌群
褐变
PRDM16
脂肪组织
褐色脂肪组织
肥胖
化学
多糖
产热素
脂质代谢
生物
食品科学
生物化学
医学
作者
Yu Wang,Ting Li,Yueyue Liu,Chengcheng Yang,Lei Liu,Xiangnan Zhang,Xingbin Yang
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:13 (24): 13014-13027
被引量:13
摘要
Heimao tea (HMT) is a kind of fermented dark tea that has various health benefits. However, the available information regarding the anti-obesity effect of HMT and its active ingredients is still limited. Herein, we extracted the polysaccharides from Heimao tea (HMTP) and evaluated the anti-obesity effect and the underlying mechanism of HMTP. 12-Week administration of HMTP ameliorated lipid accumulation in the adipose tissue and improved glucolipid metabolism in high-fat diet (HFD)-fed mice. HMTP also induced browning of inguinal white adipose tissue (iWAT) and enhanced the thermogenic activity of interscapular brown adipose tissue (iBAT) by upregulating the expression of a series of thermogenic genes, such as Ucp1, Prdm16, and Pgc1α. Interestingly, the anti-obesity effect of HMTP was closely associated with altered relative abundance of the gut microbes, especially Dubosiella and Romboutsia, with significant increases, in which the abundance of Dubosiella and Romboutsia was negatively correlated with the body weight (r = -0.567, p < 0.05; r = -0.407, p < 0.05) and positively correlated with the iBAT index (r = 0.520, p < 0.05; r = 0.315, p < 0.05). Our data suggest that the alteration of the gut microbiota may play a critical role in HMTP-induced iWAT browning and iBAT activation, and our findings may provide a promising way for preventing obesity.
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