Penetrating Keratoplasty in Active Acanthamoeba Keratitis

Purpose: To report the results of penetrating keratoplasty (PK) in active Acanthamoeba keratitis (AK). Methods: Nine patients with deep stromal infiltrates because of AK were treated with intensive antiamoebic medical therapy followed by PK during the acute infectious phase because of poor clinical response or poor compliance. Antiamoebic therapy was tapered after PK. Results: Visual acuity ranged from 20/15 to 20/50 after an average of 17 months after PK with no signs of recurrences. Patients had rapid resolution of symptoms. Conclusion: PK is a viable option for active AK not responding to maximum medical treatment.